产品货号：
Z20784
中文名称：
Mouse SMARCC1抗体
英文名称：
Anti-Mouse SMARCC1 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Mouse SMARCC1 Antibody (C-term) |
| 指标别名 | BAF155;BRG1 associated factor 155;CRACC1;Rsc8;SMARCC1;SRG3;SWI3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | IF,WB |
| 基因名称 | Smarcc1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This (Mouse) Smarcc1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 963-997 amino acids from the C-terminal region of (Mouse) Smarcc1. |
| 计算分子量 | 123kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).May stimulate the ATPase activity of the catalytic subunit of the complex.Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR),which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity).Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.As neural progenitors exit mitosis and differentiate into neurons,npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF).The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Uniprot ID | P97496 |
相关搜索：Mouse SMARCC1抗体，Mouse SMARCC1(C-term)多抗，Anti-Mouse SMARCC1 Antibody (C-term)